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KMID : 0869220100140010000
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Journal of Korean Geriatric Psychiatry
2010 Volume.14 No. 1 p.0 ~ p.0
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CREB-Phosphorylation as a Predictor of Therapeutic Response to Antidepressants
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Lee Yu-Jin
Lim Shinn-Won
Kim Su-Yeon
Chung Jae-Won
Kim Jin-Woo
Myung Woo-Jae
Song Ji-Hye
Kim Doh-Kwan
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Abstract
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Objectives: CREB (c-AMP response element binding protein) is known as a key mediator of the therapeutic response to antidepressants.
We investigated the change of CREB-phosphorylation (pCREB) at the early point of the fluoxetine treatment to find out it can be
a predictor for antidepressant response.
Methods:We evaluated the pCREB of T - lymphocyte nuclear extracts from 18 depressed patients at 0 and 1th week during fluoxetine
treatment (20 mg/day). Responders were defined as the>or =50 % reduction of HAM-D score in 4 weeks. We compared the
changes of pCREB at 0 and 1th week between responders and non-responders.
Results:The responders showed a significant increase of pCREB at week 1 compared with week 0. The HAM-D difference between
week 0 and 4 was positively correlated with the change of pCREB response.
Conclusion: These results suggest that the early change of pCREB in peripheral lymphocyte can predict the later response of antidepressant.
The correlation showed pCREB directly reflects a response status to the antidepressant fluoxetine and clinical improvement.
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KEYWORD
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CREB-phosphorylation·Depression·Predictors·Therapeutic response.
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